Clinical characteristics and diagnosis of pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma: a retrospective analysis of 29 cases.
- Author:
Ai-wu LI
1
;
Jian-fang XU
;
Cai-cun ZHOU
;
Chun-yan WU
;
Yan-li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antigens, CD20; metabolism; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Combined Modality Therapy; Cyclophosphamide; therapeutic use; Doxorubicin; therapeutic use; Drugs, Chinese Herbal; therapeutic use; Female; Follow-Up Studies; Humans; Lung; pathology; Lung Neoplasms; diagnosis; diagnostic imaging; pathology; therapy; Lymphoma, B-Cell, Marginal Zone; diagnosis; diagnostic imaging; pathology; therapy; Male; Middle Aged; Neoplasm Staging; Pneumonectomy; methods; Prednisone; therapeutic use; Proto-Oncogene Proteins c-bcl-2; metabolism; Retrospective Studies; Survival Rate; Thoracic Surgery, Video-Assisted; Tomography, X-Ray Computed; Vincristine; therapeutic use
- From: Chinese Journal of Oncology 2012;34(5):390-393
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical manifestations and radiological characteristics, diagnostic methods and outcomes of pulmonary mucosa-associated lymphoid tissue-derived(MALT) lymphoma.
METHODSA retrospective review of clinical, radiological and follow-up data of 29 pulmonary MALT lymphoma cases at Shanghai Pulmonary Hospital affiliated to Tong Ji University from January 2002 to June 2010 was performed.
RESULTSAmong these patients, there were 19(65.5%) males and 10 (34.5%) females aged from 27 to 73 (median 53) years old. Common clinical manifestations were cough (51.7%), fever (20.7%), apnea (17.2%), chest pain (17.2%), fatigue (13.8%) and weight loss (13.8%), while 9(31.0%) cases had no symptoms at diagnosis. The characteristics of the chest CT showed that 22 (75.9%) of the cases had patch infiltration or consolidation of the lung, 7(24.1%) of the cases had mass, and 15 (51.7%) unilateral and 14(48.3%) bilateral lesions. Their diagnosis duration varied between 0.5 and 96 months. 18(62.1%) cases were confirmed by surgery (15 open lung and 7 video-assisted thoracic surgery, VAST), 4 (13.8%) by percutaneous lung biopsy, 5 (17.2%) by bronchoscopic biopsy, and 2 (6.9%) by peripheral lymph node biopsy. The treatment methods included surgery, combined chemotherapy, radiotherapy and Chinese herbal medicine. The 1- and 3-year-survival rates were 92.3% and 87.4%, respectively.
CONCLUSIONSPulmonary MALT lymphoma is atypical in clinical manifestations and radiological characteristics, and easy to be misdiagnosed. Local diseases are mainly treated by operation while extensive diseases receive combined chemotherapy. A proper diagnosis is mainly based on pathological biopsy. Patients with MALT lymphoma have a favorable outcome. Poor prognosis may be connected with poor performance status and long diagnosis duration.
