Analysis of clinicopathological features and prognosis in 68 patients with chromophobe renal cell carcinoma.
- Author:
Ji-wei HUANG
1
;
Jin ZHANG
;
Bai-jun DONG
;
Wen KONG
;
Shao-xi NIU
;
Yong-hui CHEN
;
Wei XUE
;
Dong-ming LIU
;
Yi-ran HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Renal Cell; pathology; surgery; Female; Follow-Up Studies; Humans; Kidney Neoplasms; pathology; surgery; Male; Middle Aged; Neoplasm Staging; Nephrectomy; methods; Proportional Hazards Models; Retrospective Studies; Survival Rate; Tumor Burden; Young Adult
- From: Chinese Journal of Oncology 2012;34(7):510-513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathological features and prognosis of chromophobe renal cell carcinoma (ChRCC).
METHODSThe clinical data of 68 ChRCC cases treated in our department between January 2003 and September 2010 were collected and retrospectively analyzed. The prognostic factors were evaluated by Log-rank test. Kaplan-Meier survival curve was used to estimate the survival rate.
RESULTSFifty cases were treated with radical nephrectomy and 18 with partial nephrectomy. The mean tumor size was 5.7 cm (1.5 - 16.0 cm). The TNM stages were as follows: pT1aN0M0 in 25, pT1bN0M0 in 22, pT2aN0M0 in 9, pT2bN0M0 in 5, and pT3aN0M0 in 7. According to the Fuhrman grading system, 8 patients were classified as grade I, 42 cases were grade II, 14 cases were grade III, and 4 cases were grade IV. The 3-year and 5-year survival rates were 93.0% and 90.0%, respectively. The log-rank test showed that tumor size (> 7 cm vs. ≤ 7 cm) (P = 0.004), TNM stage (T1-2 vs. T3-4) (P = 0.008) and urinary collecting system invasion (P = 0.024) were associated with survival time. The multivariable Cox regression model revealed that tumor size (> 7 cm vs. ≤ 7 cm) was an independent predictor of aggressive ChRCC (P = 0.038).
CONCLUSIONSChRCC is a distinct type of renal cell carcinoma exhibiting a low degree of malignancy. Most tumors are larger, but predominantly with a favorable prognosis. Fuhrman nuclear grading is not suitable for ChRCC. Tumor size (> 7 cm vs. ≤ 7 cm) is an independent predictor of prognosis of ChRCC.
