Expression of CD4(+) and IL-17, Foxp3 in non-small cell lung cancer and their correlation with microvessel density.
- VernacularTitle:CD4 IL-17和Foxp3在非小细胞肺癌组织中的表达及意义
- Author:
Guo-qing ZHANG
1
;
Feng HAN
;
Xin-zhi FANG
;
Xiao-mei MA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antigens, CD34; metabolism; CD4 Antigens; metabolism; Carcinoma, Non-Small-Cell Lung; metabolism; pathology; Female; Forkhead Transcription Factors; metabolism; Humans; Interleukin-17; metabolism; Lung Neoplasms; metabolism; pathology; Male; Microvessels; pathology; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Platelet Endothelial Cell Adhesion Molecule-1; metabolism
- From: Chinese Journal of Oncology 2012;34(8):596-599
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of CD4(+), IL-17 and Foxp3 in non-small cell lung cancer (NSCLC) and their relationship with microvessel density (MVD).
METHODSThe expressions of CD4(+), IL-17, Foxp3, CD31 and CD34 in the cancer tissues of 102 NSCLC cases were detected by immunohistochemisty. The relationship among the expressions of CD4(+), IL-17, Foxp3 and MVD was analyzed. The count data were analyzed using χ(2) test. The measurement data were analyzed using single-factor analysis of variance, and significance level α = 0.05.
RESULTSAmong the factors affecting CD31 expression, there was a statistically significant difference between the strong positive Foxp3 expression (++) and negative (-) and positive expressions (+) in the NSCLC cancer tissues (P < 0.05), and between the expressions in stage I and III cancer tissues (P < 0.05). Among the factors affecting CD34 expression, there was a significant difference between positive IL-7 expression (+) and strong positive IL-7 expression (++) (P < 0.05), between negative Foxp3 expression (-) and strong positive Foxp3 expression (++) (P < 0.05), and between the CD34 expressions in stage I and III and between those in stage II and III NSCLC cancer tissues (P < 0.05).
CONCLUSIONSCD4, IL-17and Foxp3 may be involved in the tumor suppression caused by host immune response, and are related with the NSCLC invasion and metastasis.
