Efficacy of European Organization for Research and Treatment of Cancer (EORTC) risk tables for the prediction of recurrence and progression of non-muscle invasive bladder cancer after intravesical pirarubicin instillation.
- VernacularTitle:欧洲癌症研究与治疗组织风险评估表对预测行吡柔比星膀胱灌注化疗的膀胱肿瘤复发率及进展率的有效性分析
- Author:
Chao XU
1
;
Xian-zhou JIANG
;
Nian-zhao ZHANG
;
Lin MA
;
Zhi-shun XU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; administration & dosage; therapeutic use; Disease Progression; Doxorubicin; administration & dosage; analogs & derivatives; therapeutic use; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Retrospective Studies; Risk Assessment; Urinary Bladder Neoplasms; drug therapy; pathology
- From: Chinese Journal of Oncology 2012;34(8):609-612
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the influence of intravesical Pirarubicin (THP) instillation on the prediction results of European Organization for Research and Treatment of Cancer (EORTC) risk tables and to discuss the efficacy of EORTC risk tables in clinical application.
METHODSWe retrospectively reviewed the clinical data of 389 patients with non-muscle invasive bladder cancer after TURBT treated with intravesical pirarubicin instillation. According to the EORTC Scoring System, all the cases were divided into low risk group, intermediate risk group and high risk group. The 1-year and 5-year recurrence and progression rates of each group were calculated and compared with the prediction results of the EORTC risk tables.
RESULTSThe 1-year recurrence and progression rates of the low risk group were 8.0% and 0, those of the intermediate risk group were 31.0% and 2.8%, and those of the high risk group were 52.5% and 18.6%, respectively. The 5-year recurrence and progression rates of low risk group were 16.0% and 5.3%, those of the intermediate risk group were 42.6% and 10.7%, and those of the high risk group were 63.9% and 41.9%, respectively. The prediction results of progression rate were similar to that of the EORTC risk tables while the overall recurrence rate was lower.
CONCLUSIONSThe EORTC risk tables can be effectively used to predict the recurrence rate and progression rate of non-muscle invasive bladder cancer. However, the EORTC risk tables have a tendency to overestimate the recurrence rate. Intravesical pirarubicin instillation is helpful to reduce the recurrence rate, yet has no obvious influence on the tumor progression.
