Clinicopathological features and prognosis of primary appendiceal adenocarcinoma.
- Author:
Jian-wei LIANG
1
;
Zheng WANG
;
Zhi-xiang ZHOU
;
Xing-mao ZHANG
;
Jun-jie HU
;
Ping ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; drug therapy; metabolism; pathology; surgery; Adenocarcinoma, Mucinous; drug therapy; metabolism; pathology; surgery; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Appendectomy; methods; Appendiceal Neoplasms; drug therapy; metabolism; pathology; surgery; Carcinoembryonic Antigen; metabolism; Carcinoma, Signet Ring Cell; drug therapy; metabolism; pathology; surgery; Female; Fluorouracil; administration & dosage; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Proportional Hazards Models; Retrospective Studies; Survival Rate; Young Adult
- From: Chinese Journal of Oncology 2012;34(8):616-619
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinicopathological characteristics and prognostic factors of primary appendiceal adenocarcinoma.
METHODSThe clinicopathological data of 42 patients with primary appendiceal adenocarcinoma treated in the Cancer Hospital of Chinese Academy of Medical Sciences between March 1994 and October 2009 were retrospectively analyzed. The survival analysis was conducted using Kaplan-Meier method. The factors influencing survival were analyzed using univariate (Log-rank) and multivariate (Cox) models.
RESULTSA total of 42 patients (29 female and 13 males, median age 56 years) with appendiceal adenocarcinoma were included in this study. Of them, 26 (61.9%) were mucinous adenocarcinoma, 12 (28.6%) were intestinal-type adenocarcinoma and 4 (9.5%) were signet cell carcinoma. 18 patients underwent curative resection, 20 patients received cytoreductive surgery, and 4 patients underwent biopsy only. Thirty patients received systemic chemotherapy (5-Fu-based regimens). One patient who died of postoperative pulmonary embolism on day 8 was excluded from the survival analysis. The overall 1-, 3-, and 5-year survival rate was 80.3%, 46.0% and 38.3%, respectively. Univariate analysis revealed that presence of symptoms of acute appendicitis, curative resection, histological grade, histological subtype, preoperative CEA level, systematic chemotherapy, and stage were all significant factors affecting the survival. Multivariate analysis showed that the preoperative CEA level (P = 0.01), histological grade (P = 0.001), and stage (P = 0.001) were independent prognostic factors.
CONCLUSIONSHigh level of CEA, G2/3 grade, and advanced stage are associated with poor prognosis in patients with primary appendiceal adenocarcinoma.
