Analysis of prognostic factors of non-small cell lung cancer in patients under 40 years of age.
- Author:
Chun-hua XU
1
;
Li-ke YU
;
Yu ZHANG
;
Hai-yan XIE
;
Ke-ke HAO
;
Wei HU
;
Ning XIA
;
Ping ZHAN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Carcinoembryonic Antigen; blood; Carcinoma, Non-Small-Cell Lung; blood; drug therapy; pathology; radiotherapy; surgery; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Karnofsky Performance Status; Lung Neoplasms; blood; drug therapy; pathology; radiotherapy; surgery; Male; Neoplasm Staging; Pneumonectomy; methods; Proportional Hazards Models; Retrospective Studies; Survival Rate; Young Adult
- From: Chinese Journal of Oncology 2012;34(9):703-705
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the prognostic factors for non-small cell lung cancer(NSCLC)in patients under 40 years of age.
METHODSThe clinicopathological data of 148 young patients with NSCLC were retrospectively analyzed. Kaplan-Meier and Cox regression analyses were used to analyze the relationship between prognostic factors and survival time.
RESULTSThe patients were followed-up for 6 - 148 months, and the follow-up rate was 100%. In the whole group, 122 patients died and 26 cases were surviving. The 1-, 3- and 5-year survival rates were 54.7%, 10.4% and 5.6%, respectively. The median survival time (MST) was 14.7 months. Kaplan-Meier analysis showed that Karnofsky performance status (KPS), clinical stage, treatment modality and serum CEA were related with prognosis (P < 0.05). Multivariate analysis indicated that KPS, clinical stage, treatment modality and serum CEA were independent prognostic factors (P < 0.05).
CONCLUSIONSKPS, CEA, clinical stage and treatment modalities are independent prognostic factors in young NSCLC patients.
