Expression of MICA/B protein in esophageal cancer and its clinical significance.
- VernacularTitle:食管癌组织中主要组织相容性复合体-Ⅰ类分子链相关蛋白A/B表达及其临床意义
- Author:
Jia-zhuan MEI
1
;
Ji-zhi ZHAO
;
Guang-ying YANG
;
Fang-fang GAO
;
Gui-ju LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; metabolism; Esophageal Neoplasms; diagnosis; metabolism; pathology; Female; Histocompatibility Antigens Class I; metabolism; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Grading; Up-Regulation
- From: Chinese Journal of Oncology 2012;34(10):745-747
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.
METHODSThe expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.
RESULTSThe positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).
CONCLUSIONMICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.
