Clinical and angiographic outcome in coronary artery disease patients with type-II diabetes mellitus undergoing elective bare-metal stenting or drug-eluting stenting.
- Author:
Shu-bin QIAO
1
;
Qing HOU
;
Bo XU
;
Jue CHEN
;
Hai-bo LIU
;
Yue-jin YANG
;
Yong-jian WU
;
Jin-qing YUAN
;
Yuan WU
;
Jun DAI
;
Shi-jie YOU
;
Wei-hua MA
;
Pei ZHANG
;
Zhan GAO
;
Ke-fei DOU
;
Hong QIU
;
Chao-wei MU
;
Ji-lin CHEN
;
Run-lin GAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Angioplasty, Balloon, Coronary; Coronary Artery Disease; complications; therapy; Diabetes Mellitus, Type 2; complications; therapy; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Treatment Outcome
- From: Chinese Journal of Cardiology 2007;35(6):523-526
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the clinical and angiographic outcome in patients with type-II diabetes mellitus undergoing drug-eluting stent (DES) or bare-metal stent (BMS).
METHODSA total of 139 consecutive diabetic patients (114 males) with coronary disease who underwent successful elective percutaneous coronary intervention with DES (n = 83 with 151 lesions) or BMS (n = 56 with 70 lesions) on native coronary arteries from April 2004 to August 2005 at our institution were included in this study. All patients were treated according to guidelines and coronary angiography was repeated at 6 months post procedure in all patients. Aspirin (300 mg/d) and clopidogrel (75 mg/d) were administered till 6 months after the procedure.
RESULTSThere were 42.5% C type by ACC/AHA and 19.0% total occlusion lesions. The average stent length of each lesion was 26.53 +/- 14.72 mm, and mean reference diameter was 2.80 +/- 0.43 mm. Baseline characteristics were similar between DES and BMS groups except lower mean reference vessel diameter in DES than that of BMS group (2.71 +/- 0.41 mm vs. 2.98 +/- 0.53 mm, P < 0.001). The in stent restenosis rate at 6 months (10.6% vs. 38.6%, P < 0.001) and in-segment late loss (0.24 +/- 0.56 mm vs. 0.91 +/- 0.77 mm, P < 0.001) were significantly lower in DES group than those of BMS group. The target lesion revascularization (TLR) incidence was also significantly lower in DES group compared to BMS group (8.6% vs. 30.0%, P < 0.001). However, 4 late in-stent thrombosis were seen in DES group and none in BMS group of DES (P = 0.148).
CONCLUSIONDES implantation in patients with diabetes mellitus is associated with lower in-stent restenosis and TLR rates compared to BMS implantation 6 months after procedure and attention should be paid on late in-stent thrombosis after DES implantation.