Safety and efficacy comparison of myocardial contrast enhancement-guided and angio-pressure-guided transcoronary ablation of septal hypertrophy for patients with hypertrophic obstructive cardiomyopathy.
- Author:
Yue-chun GAO
1
;
Yu LI
;
Xue-si WU
;
Chang-qi JIA
;
Teng-yong JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cardiac Catheterization; methods; Cardiomyopathy, Hypertrophic; diagnostic imaging; therapy; Catheter Ablation; methods; Female; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Ultrasonography
- From: Chinese Journal of Cardiology 2007;35(6):540-543
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the safety and efficacy of myocardial contrast enhancement (MCE)-guided and angio-pressure (AP)-guided transcoronary ablation of septal hypertrophy (TASH) for patients with hypertrophic obstructive cardiomyopathy (HOCM).
METHODSTASH was performed under MCE-guide (n = 47, group I) or AP-guide (n = 25, group II) for drug-refractory patients with HOCM. Myocardial perfusion imaging (MPI) data as well as other clinical data were compared.
RESULTSTASH both under MCE-guide or AP-guide resulted in similar and significant reduction of left ventricular outflow tract gradient (PG) and associated with significant symptom improvement (all P < 0.001). Dosage of ethanol use, peak-level of CK-MB and ablated myocardial area and incidence of arrhythmia were also similar between the two groups.Similar left ventricular/atrial dimension changes post TASH were observed in the 2 groups during follow-up. However, the first selected septal vessels were changed under MCE in 6 patients.
CONCLUSIONSOur data demonstrated that the MCE-guided TASH was not superior to AP-guided TASH in safety and efficacy. However, MCE-guided TASH can avoid the misplace of ethanol to avoid innocent myocardial ablation.
