Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients.
- Author:
Nian-xin JIANG
1
;
Jie SONG
;
Biao XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; genetics; Dose-Response Relationship, Drug; Female; Genotype; Humans; International Normalized Ratio; Male; Middle Aged; Mixed Function Oxygenases; genetics; Polymorphism, Single Nucleotide; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin; administration & dosage
- From: Chinese Journal of Cardiology 2007;35(7):652-654
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients.
METHODGenotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin.
RESULTSTT genotype was found in 83 patients (81.4%), CT genotype in 16 patients (15.7%) and CC genotype in 3 patients (2.9%). To achieve similar target INR range (1.5 - 2.5), the warfarin dose requirement was significantly lower in patients with TT genotype than that in patients with CT/CC genotypes (P < 0.01).
CONCLUSIONC1173T polymorphism in the VKORC1 gene might be one important determinant for warfarin dose requirement in Chinese patients.
