Increased plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients.
- Author:
Zuo-guang WANG
1
;
Jie-lin LIU
;
Ya LIU
;
Shao-jun WEN
;
Jie WEN
;
Ya-ping LIU
;
Xin-jun CHEN
;
Zhao-su WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Angiotensin II; blood; Antioxidants; Blood Pressure; physiology; Calcitonin Gene-Related Peptide; blood; Case-Control Studies; Endothelins; blood; Female; Glutathione Peroxidase; blood; Humans; Hypertension; blood; Male; Middle Aged; Nitric Oxide Synthase; blood; Plasma; metabolism; Superoxide Dismutase; blood; Vasopressins; blood
- From: Chinese Journal of Cardiology 2007;35(8):719-722
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study investigates the plasma vasoactive substances and antioxidant enzymes levels in prehypertensive patients.
METHODSPatients were scruited according to JNC-7 and divided into three groups: 74 normotensive subjects (NT group, 38 males, mean age 47.15 +/- 7.77 years old); 51 prehypertensive patients (PH group, 29 males, mean age 47.82 +/- 5.16 years old) and 71 essential hypertensive patients (EH group, 37 males, mean age 48.25 +/- 7.97 years old). Serum lipids and plasma angiotensin II (Ang II), endothelin (ET), vasopressin (AVP), calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), superoxide dismutase (SOD) and glutathione peroxidase (GPX) by radioimmunoassay and enzyme linked immunosorbent assay.
RESULTSSerum Lipids (TG, CHO and LDL) were significantly higher in the PH and EH groups compared to NT group (all P < 0.05). Ang II, AVP and ET were significantly increased while CGRP decreased in the EH group than that in NT group (all P < 0.05). SOD was significantly lower while GPX significantly higher. Further more, in the PH and EH groups than those in the NT group (all P < 0.05).
CONCLUSIONSOD was reduced and GPX increased in prehypertensive patients.
