Experimental Study of Energy Metabolism in the Acute Phase of Spinal Cord Injury.
- Author:
Kyun Man SHIN
1
Author Information
1. Department of Neurosurgery, Ewha Womans University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Spinal cord injury;
Energy metabolism;
ATP;
Glucose lactate;
Prognostic factors
- MeSH:
Adenosine;
Adenosine Triphosphate;
Animals;
Cats;
Energy Metabolism*;
Glucose;
Ketamine;
Lactic Acid;
Metabolism;
Spinal Cord Injuries*;
Spinal Cord*
- From:Journal of Korean Neurosurgical Society
1982;11(4):423-431
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is the purpose of this study to determine the alterations of the metabolism on the feline spinal cord following trauma. Cats were anesthetized with ketamine hydrocloride and injured with a 400 gm-cm impact injury to L-2 level of spinal cord. Biochemical analysis of the injured segment revealed signicifant depletion in the concentrations of adenosine triphosphate(ATP) for the entire 24-hour postinjury period. Glucose concentrations were elevated significantly for the entire 24-hour period, and especially marked elevated between 8 and 24 hours. Lactate concentrations were elevated at 1 hour and between 1 and 4 hours. but especially significantly declined between 8 and 24 hours. This sequence of the metabolic changes suggested that anaerobic metabolism likely predominated for the initial 4 hours, and between 8 and 24 hours there appeared to be an increasing percentage of oxidative metabolism in the remaining metabolically viable tissues.
