Correlation analysis between quality characteristics and commercial specifications of Panacis Quinquefolii Radix.

Dan Zhang; Kai-yan Zheng; Lan-fang WU; Run-huai Zhao; Fang-jie Hou; Qian Wang; Hui-ling You; Li-hong DU; Lu-qi Huang; Yu-guang Zheng

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Correlation analysis between quality characteristics and commercial specifications of Panacis Quinquefolii Radix.

Author: Dan ZHANG ¹ ; Kai-Yan ZHENG ¹ ; Lan-Fang WU ¹ ; Run-Huai ZHAO ² ; Fang-Jie HOU ¹ ; Qian WANG ¹ ; Hui-Ling YOU ¹ ; Li-Hong DU ¹ ; Lu-Qi HUANG ³ ; Yu-Guang ZHENG ¹
Author Information

1. College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
2. China National Group Corp. of Traditional&Herbal Medicine, Beijing 102600, China.
3. State Key Laboratory of Dao-di Herbs, National Resources Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Publication Type:Journal Article
Keywords: HPLC; Panacis Quinquefolii Radix; fingerprint; grade specification; quality evaluation
From: China Journal of Chinese Materia Medica 2016;41(18):3329-3335
CountryChina
Language:Chinese
Abstract: This study was aimed to analyze the correlation between commercial specifications of Panacis Quinquefolii Radix and quantitative indexes of sevent kinds of ginsenosides (ginsenosides Rg¹, Re, Rb¹, Rc, Rb₂, Rb₃, Rd) contained in Panacis Quinquefolii Radix by using high performance liquid chromatography (HPLC), explore the correlation between the characteristics of the traditional Panacis Quinquefolii Radix specifications and modern chemical quantitative indicators, and provide a theoretical basis for the quality grade evaluation of Panacis Quinquefolii Radix. The HPLC fingerprint method was used to analyze 40 batches of Panacis Quinquefolii Radix. A total of 19 peaks were marked, and the similarity was above 0.900 for all samples. On this basis, processing methods, product specifications, contents of 7 components, and the total contents of ginsenoside Rg¹, Re and Rb¹ were used as the original variables for cluster analysis and principal component analysis. The results showed great correlation between the quality of Panacis Quinquefolii Radix and the information on their origins, but the difference was less with the characteristics of traditional commercial specifications, indicating some limitations in the division of commercial specifications of Panacis Quinquefolii Radix. The results revealed the intrinsic relationship between the product specifications, traditional qualitative indexes, and quantitative indexes of chemical components of Panacis Quinquefolii Radix, providing a new idea for the objective comprehensive evaluation of the quality of Panacis Quinquefolii Radix.