Comprehensive analysis on

Hui-ling HU; Chao-mei FU; Xuan Zhao; Jin-ming Zhang; Fei Gao; Yao HE; Shu FU; Ling LI

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Comprehensive analysis on "toxicity and effect" of Chinese pharmaceutical preparations.

Author: Hui-Ling HU ¹ ; Chao-Mei FU ¹ ; Xuan ZHAO ¹ ; Jin-Ming ZHANG ² ; Fei GAO ³ ; Yao HE ¹ ; Shu FU ¹ ; Ling LI ⁴
Author Information

1. Pharmacy College, Chengdu University of Traditional Chinese Medicine, the Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China.
2. University of Macao, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research Macao University of Traditional Chinese Medicine, Macao 999078, China.
3. College of Traditional Chinese Medicine, University of Hong Kong, Li Ka Shing Faculty of Medicine, Hong Kong 999077, China.
4. Food and Bio-engineering College, Xihua University, Chengdu 610039, China.
Publication Type:Journal Article
Keywords: "toxicity and effect" relationship; Chinese pharmaceutical preparations; manufacturing process
From: China Journal of Chinese Materia Medica 2016;41(18):3483-3489
CountryChina
Language:Chinese
Abstract: The manufacturing process of Chinese medicines is the significant link to achieve "effect-enhancing and toxicity-reducing", including an interaction between "toxicity and effect". This paper would elucidate the effects of Chinese herbal compound decoction, preparation, dosage forms, route of administration and quality of pharmaceutical excipients on "toxicity-effect" theory from the formulation approaches. The article pointed out that the comprehensive analysis on "toxicity-effect" theory should be strengthened from the aspects of overall manufacturing, fundamental research and modern Chinese preparation, to explore the mechanism of "effect-enhancing and toxicity-reducing" in the manufacturing process, clarify the core status of Chinese preparation in "toxicity-effect" theory, and ensure the security and effectiveness in traditional Chinese medicine clinical application.