Near infrared spectroscopy based process trajectory technology and its application in monitoring and controlling of traditional Chinese medicine manufacturing process.
- Author:
Wen-Long LI
1
;
Hai-Bin QU
1
Author Information
- Publication Type:Journal Article
- Keywords: near infrared spectroscopy; process analytical technology; process monitoring and controlling; process trajectory; traditional Chinese medicine manufacturing
- From: China Journal of Chinese Materia Medica 2016;41(19):3506-3510
- CountryChina
- Language:Chinese
- Abstract: In this paper, the principle of NIRS (near infrared spectroscopy)-based process trajectory technology was introduced.The main steps of the technique include:① in-line collection of the processes spectra of different technics; ② unfolding of the 3-D process spectra;③ determination of the process trajectories and their normal limits;④ monitoring of the new batches with the established MSPC (multivariate statistical process control) models.Applications of the technology in the chemical and biological medicines were reviewed briefly. By a comprehensive introduction of our feasibility research on the monitoring of traditional Chinese medicine technical process using NIRS-based multivariate process trajectories, several important problems of the practical applications which need urgent solutions are proposed, and also the application prospect of the NIRS-based process trajectory technology is fully discussed and put forward in the end.
