Protective effect of velvet antler polypeptide (VAP) on rats with the spinal cord injury.
- Author:
Zhen-hua LI
1
;
Xiang-yang LENG
;
Zhong-li GAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antlers; chemistry; Male; Peptides; therapeutic use; Rats; Rats, Wistar; Spinal Cord; pathology; Spinal Cord Injuries; drug therapy; pathology
- From: China Journal of Orthopaedics and Traumatology 2008;21(4):285-286
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effect of antler polypeptide on the rats with spinal cord injury (SCI).
METHODSThe model rats were treated with different doses of antler polypeptide, and its effect on motor function, ethology and pathological changes of spinal cord of the rats observed.
RESULTSSeven days after treatment with different doses of antler polypeptide, rat's motor activity was recovered in some extent. Significant difference (P < 0.001)was found between the antler polypeptide treatment group and operation group. The effect could be enhanced by increase of the doses. We observerd the effect on the pathological change of spinal cord in rat, and found the tissue edema and inflammatory infiltration were relieved after treatment with different doses of antler polypeptide, especially in the dose of 15 mg antler polypeptide.
CONCLUSIONAntler polypeptide can promote the motor function recovery in SCI rats, and its action is dose-dependent.
