Variability of Response Time as a Predictor of Methylphenidate Treatment Response in Korean Children with Attention Deficit Hyperactivity Disorder.
10.3349/ymj.2009.50.5.650
- Author:
Seung Hye LEE
1
;
Dong Ho SONG
;
Bung Nyun KIM
;
Yoo Sook JOUNG
;
Eun Hye HA
;
Keun Ah CHEON
;
Yee Jin SHIN
;
Hee Jeong YOO
;
Dong Won SHIN
Author Information
1. Department of Psychiatry, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea. ntour@unitel.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
ADHD;
methylphenidate;
response time variability
- MeSH:
Adolescent;
Attention Deficit Disorder with Hyperactivity/*drug therapy;
Child;
Female;
Humans;
Korea;
Male;
Methylphenidate/*therapeutic use;
*Reaction Time;
Treatment Outcome
- From:Yonsei Medical Journal
2009;50(5):650-655
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Methylphenidate (MPH) is an effective medication for the treatment of attention deficit hyperactivity disorder (ADHD). However, about 30% of patients do not respond to or are unable to tolerate MPH. Based on previous findings, we hypothesized that great variability in response time (RT) among Korean children with ADHD on a computerized continuous performance attention test would be related to poor MPH treatment response. MATERIALS AND METHODS: Children (ages 6-18 years) with ADHD were recruited for a prospective 12-week, open-labeled, multicenter study to examine optimal dosage of OROS methylphenidate. Of the 144 subjects selected, 28 dropped out due to adverse events, medication noncompliance, or follow-up loss, and an additional 26 subjects with comorbid disorders were excluded from statistical analyses. We defined 'responders' as subjects who received a score of less than 18 on the attention deficit hyperactivity disorder rating scale (ARS; Korean version, K-ARS) and a score of 1 or 2 on the Clinical Global Impression-Improvement scale (CGI-I). RT variability was assessed with the ADHD diagnostic system (ADS). RESULTS: Fifty-nine (67%) subjects responded to MPH treatment. The non-responders showed greater RT variability at baseline (Mann Whitney U = 577.0, p < 0.01). Baseline RT variability was a significant predictor of MPH response (Nagelkerke R2 = 0.136, p < 0.01). It predicted 94.9% of responder, 17.2% of non-responder and 69.3% of overall group. CONCLUSION: High RT variability may predict poor response to MPH treatment in children with ADHD.
