- Author:
Lin YANG
1
;
ChunSheng LI
;
ChunJin GAO
;
Shuo WANG
;
XianFei JI
;
ZhiYu SU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Pressure; Cardiopulmonary Resuscitation; Coronary Circulation; Heart Arrest; Hemodynamics; Male; Myocardial Contraction; physiology; Myocardial Stunning; Swine; Time Factors; Ventricular Fibrillation
- From: Biomedical and Environmental Sciences 2011;24(2):155-162
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate cardiac function and myocardial perfusion during 48 h after cardiopulmonary resuscitation (CPR), further to test myocardial stunning and seek indicators for long-term survival after CPR.
METHODSAfter 4 min of untreated ventricular fibrillation, fifteen anesthetized pigs were studied at baseline and 2 h, 4 h, 24 h, and 48 h after restoration of spontaneous circulation (ROSC). Hemodynamic data, echocardiography and gated-single photon emission computed tomography myocardial perfusion images were carried out.
RESULTSMean arterial pressure (MAP), coronary perfusion pressure (CPP) and cardiac troponin I (CTNI) showed significant differences between eventual survival animals and non-survival animals at 4 h after ROSC (109.2 ± 10.7 mmHg vs. 94.8 ± 12.3 mmHg, P=0.048; 100.8 ± 6.9 mmHg vs. 84.4±12.6 mmHg, P=0.011; 1.60 ± 0.13 ug/L vs. 1.75 ± 0.10 ug/L, P=0.046). Mitral valve early-to-late diastolic peak velocity ratio, mitral valve deceleration time recovered 24 h; ejection faction and the summed rest score recovered 48 h after ROSC.
CONCLUSIONCardiac systolic and early active relaxation dysfunctions were reversible within survival animals; cardiac stunning might be potentially adaptive and protective after CPR. The recovery of MAP, CPP, and CTNI could be the indicators for long-term survival after CPR.