Cigarette smoking increases risk for incident metabolic syndrome in Chinese men-Shanghai diabetes study.
- Author:
YunXia ZHU
1
;
MingLiang ZHANG
;
XuHong HOU
;
JunXi LU
;
LiangPu PENG
;
HuiLin GU
;
Chen WANG
;
WeiPing JIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Blood Glucose; metabolism; Body Mass Index; China; epidemiology; Cholesterol, HDL; blood; Diabetes Mellitus; blood; epidemiology; Follow-Up Studies; Humans; Hypertriglyceridemia; blood; epidemiology; Male; Metabolic Syndrome; blood; epidemiology; etiology; Middle Aged; Odds Ratio; Risk Factors; Smoking; adverse effects; blood; epidemiology; Waist Circumference
- From: Biomedical and Environmental Sciences 2011;24(5):475-482
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine whether smoking increases the risk for developing metabolic syndrome (MetS) in Chinese men.
METHODSA total of 693 men with no MetS at baseline were followed for 2.9-5.5 years. Subjects were divided into nonsmokers, ex-smokers, and current smokers according to baseline smoking status.
RESULTSAfter adjusting for age, education level, alcohol intake, fasting plasma insulin, HOMA-IR index, and BMI at baseline and weight change, current smokers were dose-dependently associated with increased risk for developing new MetS compared with nonsmokers. The odds ratio (OR) was 2.131 (95% CI, 1.264, 3.592; P<0.01) for the NCEPIII definition or 3.083 (95% CI, 1.807, 5.295; P<0.01) for the JCDCG definition of MetS. Ex-smokers who had quit for ≥13 years significantly decreased the risk for developing new MetS defined by the JCDCG definition. Compared with nonsmokers, current smokers were significantly associated with increased incidence of hypertriglyceridemia and low HDL-C.
CONCLUSIONSmoking is a risk factor for developing MetS in Chinese men after adjusting for age, education level, alcohol intake, fasting plasma insulin, HOMA-IR, BMI, and weight change. This could be due to an increased incidence of dyslipidemia. Smoking cessation for >13 years decreased the risk for developing MetS defined by the JCDCG definition.
