Effect of Chinese drugs for jianpi huayu on healing quality of gastric ulcer in rats.
- Author:
Jian-ping LIU
1
;
Dong-ju HU
;
Quan-he ZONG
;
Zhiqiang CHEN
;
Bingzhan NIU
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; Animals; Anti-Ulcer Agents; pharmacology; Drugs, Chinese Herbal; pharmacology; Epidermal Growth Factor; metabolism; Gastric Mucosa; metabolism; pathology; physiopathology; Male; Random Allocation; Rats; Rats, Wistar; Receptor, Epidermal Growth Factor; metabolism; Stomach Ulcer; chemically induced; physiopathology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(7):635-637
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Chinese drugs of Jianpi Huayu (JPHY, strengthening Pi and dissolving stasis) on healing quality of gastric ulcer and its mechanism.
METHODSThe gastric ulcer model was established by subserous injection of ethanoic acid in rats. Rats were randomly divided into 4 groups, the blank group, the model group, the ranitidine (RT) group and the JPHY group. Quantity of regenerative mucosa of healed gastric ulcer was determined using HE stain, epidermal growth factor (EGF) content in serum and stomach mucosa was detected by RIA and epidermal growth factor receptor (EGFR) protein expression was determined by immunohistochemistry.
RESULTSThickness of regenerated mucosa in the CHM group was higher than that in the model group and the RT group (P<0.05 or P<0.01); EGF content in mucosa in the JPHY group and the RT group was higher than that in the model group (P<0.01) and EGFR protein expression in the JPHY group was higher than that in the model group (P<0.05).
CONCLUSIONJPHY could improve the proliferation of epithelial cells, inhibit gastric acid, improve microcirculation of gastric mucosa through the mediation of EGFR, so as to elevate the healing quality of gastric ulcer, display its anti-ulcer action.
