Effect of total glucosides of Centella asiatica on antagonizing liver fibrosis induced by dimethylnitrosamine in rats.
- Author:
Zhi-jun MING
1
;
Shi-zeng LIU
;
Li CAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Centella; chemistry; Dimethylnitrosamine; Drugs, Chinese Herbal; pharmacology; Female; Glucosides; isolation & purification; pharmacology; Liver Cirrhosis, Experimental; chemically induced; drug therapy; prevention & control; Liver Function Tests; Male; Random Allocation; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(8):731-734
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the anti-liver fibrosis effect of total glucosides of Centella asiatica (GCA) in experimental rats.
METHODSRat liver fibrosis model was induced by injecting dimethylnitrosamine (DMN) intraperitoneally for 6 weeks. Rats were randomly divided into 6 groups, the normal group, the model group, the positive control group treated by colchicine, and the three GCA groups treated by high, moderate and low dosage of GCA through gastrogavage started simultaneously with the modeling. At the end of the experiment, levels of serum total protein (TP), albumin (ALB), alanine transaminase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN) were measured, and the pathology of liver tissue was observed.
RESULTSThe liver function in the GCA groups was improved, the levels of serum ALT, AST, HA were significantly lower than those in the model group (P < 0.05). Histopathological observation showed that GCA has significant anti-liver fibrosis effect.
CONCLUSIONGCA has significant preventive and therapeutic effect on DMN induced liver fibrosis in rats.
