Effect of oral administration of guanxin II decoction on coronary blood flow and cardiac systolic/diastolic function in healthy males.
- Author:
Hong-quan GAN
1
;
Xi HUANG
;
Xin-qiao TIAN
;
Yongsheng ZHU
;
Shanhong ZHANG
;
Jun LI
;
Ping REN
;
Qibing MEI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Blood Flow Velocity; drug effects; Coronary Circulation; drug effects; Coronary Disease; drug therapy; Coronary Vessels; drug effects; ultrastructure; Diastole; drug effects; Drugs, Chinese Herbal; pharmacology; Echocardiography; Heart Rate; drug effects; Humans; Male; Middle Aged; Systole; drug effects; Vasodilator Agents; pharmacology; Ventricular Function, Left; drug effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(9):785-789
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of oral administration of guanxin II decoction (GX II) on cardiovascular function, especially on the dynamics of coronary blood flow in healthy males.
METHODSChanges of heart rate, diastolic pressure, systolic pressure, left ventricular ejection fraction (LVEF), E peak, A peak, E/A value of mitral flow, diastolic peak velocity (Vmax) and diastolic flow velocity time integrals (VTI) of left anterior descending coronary artery (LAD) in 11 healthy male subjects were measured before and after oral administration of GX II, using non-invasive echocardiogram.
RESULTSCompared with those before GX II administration, the changes after administration in heart rate, systolic pressure, diastolic pressure, LVEF, E peak, A peak and E/A value, were insignificantly different (P>0.05), but the Vmax and VTI significantly increased at 30 min, 60 min, 90 min and 120 min after GX II administration (P<0.05).
CONCLUSIONTo increase the coronary blood flow is possibly one of the mechanisms of GX II in treating coronary heart disease and angina pectoris.
