Effect of jianxin pinglu pill on arrhythmia and aquaporin 4 expression in rats with myocardial ischemia/reperfusion injury.
- Author:
Xu-ping HE
1
;
Dong-feng CHEN
;
Jian-hong ZHENG
;
Shaohui DU
;
Bin DENG
;
Shangbin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Arrhythmia Agents; pharmacology; Aquaporin 4; Aquaporins; analysis; biosynthesis; Arrhythmias, Cardiac; metabolism; prevention & control; Drugs, Chinese Herbal; pharmacology; Female; Male; Myocardial Reperfusion Injury; complications; metabolism; Rats; Rats, Sprague-Dawley; Water-Electrolyte Balance; drug effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(9):823-826
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of jianxin pinglu pill (JPP) on arrhythmia and aquaporin 4 (AQP4) in rats with myocardial ischemia/reperfusion (I/R) injury.
METHODSThe effects of JPP on arrhythmia, mortality and AQP4 on I/R injured rats model induced by blocking left coronary artery were observed using II lead of ECG, HE stain and AQP4 immunohistochemical stain.
RESULTSJPP showed significant effect in lowering the arrhythmia occurrence and mortality, reducing myocardial ischemic edema and injury, strengthening AQP4 expression in myocardial tissue.
CONCLUSIONJPP has the effect of preventing I/R induced arrhythmia, it might be related with its action in up-regulating AQP4 expression level in myocardium and reducing the intracellular edema.
