Effect of mailuoning on C-Fos protein expression in rats with cerebral infarction.
- Author:
Zhi-li GUO
1
;
Ping LIU
;
Yong-hong CHEN
;
Jian SHANG
;
Liubao ZHANG
;
Chunning SHENG
;
Yun LUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cerebral Infarction; etiology; genetics; metabolism; Drugs, Chinese Herbal; pharmacology; Male; Neuroprotective Agents; pharmacology; Photochemistry; Proto-Oncogene Proteins c-fos; biosynthesis; genetics; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(9):831-834
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effect of mailuoning (MLN) on nerve cells after cerebral infarction induced by photochemistry.
METHODSEighty SD rats were divided into three groups, the control group (n = 20), the model group (n = 30) and the MLN group (n = 30). Focal cerebro-ischemia induced by photothrombosis in adult rat was used as a model. Changes of C-Fos protein expression before and after MLN treatment were observed using immunohistochemistry, computerized imaging technique and transmission electron microscopy (TEM).
RESULTSC-Fos positive cells located in the transitional zone between the necrotic core and normal cortex. C-Fos protein expression began to show 3 hrs after cerebral infarction, peaked at 6 hrs. As compared with the model group, C-Fos expression was significantly reduced in the MLN group (P<0.01).
CONCLUSIONMLN could markedly reduce the injury of nerve cell in the transitional zone, the protection may be related with its inhibition on C-Fos protein expression.
