Study on relationship between TCM Syndrome types (Xin-qi and Xin-yang deficiency) and contents of cytokines (tumor necrosis factor-alpha and interleukins) in patients with congestive heart failure.
- Author:
Rui CHEN
1
;
Feng-xia LIANG
;
Yan-xia HUANG
;
Bin LI
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Diagnosis, Differential; Female; Heart Failure; blood; physiopathology; Humans; Interleukin-1; blood; Interleukin-10; blood; Interleukin-6; blood; Male; Medicine, Chinese Traditional; Middle Aged; Myocardial Contraction; Stroke Volume; physiology; Tumor Necrosis Factor-alpha; metabolism; Ventricular Dysfunction, Left; physiopathology; Ventricular Function, Left; Yang Deficiency; blood; Yin Deficiency; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(10):876-878
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between TCM Syndromes types, Xin-qi deficiency (XQD) and Xin-yang deficiency (XYD), and contents of cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), IL-1beta and IL-10 in patients with congestive heart failure (CHF).
METHODSSixty-seven CHF in-patients with Xin-qi deficiency or Xin-yang deficiency syndrome were enrolled, their NYHA (New York Heart Association) cardiac function was assessed, ejection fraction (EF) and E peak/A peak (E/A) ratio were determined by Doppler ultrasonic echocardiograph, and serum TNF-alpha, II-6, IL-1beta and IL-10 were measured by double antibody sandwich ELISA assay.
RESULTSThe cardiac function grading in patients of XQD was mostly of I and II grade, while that in patients of XYD was mostly of III and IV grade (by Ridit analysis, P<0.01). The E/A and EF values were higher in patients of XQD than those in patients of XYD (P<0.01). Levels of TNF-alpha, IL-6 and IL-1beta were higher and IL-10 was lower in patients of XYD than those in patients of XQD (P<0.05 or P<0.01) respectively.
CONCLUSIONTNF-alpha, IL-6, IL-1beta and IL-10 probably play an important role in the development process of XQD to XYD, and could be taken as the microcosmic indexes for differentiation of the two syndromes.
