Effect of compound Salvia injection on blood coagulation in patients with traumatic cerebral infarction.
- Author:
Rong-jun ZHANG
1
;
Chao YOU
;
Bo-wen CAI
;
Yuqing WAN
;
Min HE
;
Hao LI
Author Information
- Publication Type:Clinical Trial
- MeSH: Blood Coagulation; drug effects; Brain Injuries; complications; Cerebral Infarction; drug therapy; etiology; Drugs, Chinese Herbal; therapeutic use; Female; Free Radical Scavengers; therapeutic use; Humans; Injections, Intravenous; Male; P-Selectin; blood; Phytotherapy; Salvia miltiorrhiza; chemistry; Superoxide Dismutase; blood; von Willebrand Factor; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2004;24(10):882-884
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of compound Salvia injection (CSI) on blood coagulatory function in patients with traumatic cerebral infarction (TCI).
METHODSSixty-four patients with TCI were randomly divided into two groups, 32 in each group. The treated group were treated with CSI plus conventional treatment of western medicine, and the control group treated with conventional treatment alone. Changes of symptoms, levels of plasma P-selectin (P-S), von Willebrand's factor (vWf) and D-dimer were observed with ELISA.
RESULTSThe treated group was superior to the control group in Glasgow outcome scale (P < 0.01). Before treatment, the levels of plasma P-S, vWf and D-dimer in the TCI patients were higher than those in healthy people. After treatment, all the parameters lowered in both groups, but the effect of lowering was greater in the treated group than that in the control group.
CONCLUSIONBlood coagulation disorder exists in patients with TCI, CSI could improve it, and might alleviate the cerebral damage to a certain extent.
