The change of intestinal mucosa barrier in chronic severe hepatitis B patients and clinical intervention.
- Author:
Huai-Yu SONG
1
;
Chun-Hua JIANG
;
Jian-Rong YANG
;
Qiu-Hong CHEN
;
Jun HUANG
;
Yun-Hua HUANG
;
Lie-Xin LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Adolescent; Adult; Amine Oxidase (Copper-Containing); blood; Antiviral Agents; pharmacology; therapeutic use; Child; Endotoxins; blood; Female; Glutamine; pharmacology; therapeutic use; Hepatitis B, Chronic; drug therapy; metabolism; physiopathology; Humans; Intestinal Mucosa; drug effects; metabolism; physiopathology; Intestine, Small; Lactulose; urine; Male; Mannitol; urine; Middle Aged; Permeability; Treatment Outcome; Young Adult
- From: Chinese Journal of Hepatology 2009;17(10):754-758
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the change of intestinal mucosa barrier in chronic severe hepatitis B patients and clinical intervention.
METHOD(1) 30 normal healthy controls and 60 chronic severe hepatitis B patients were enrolled in this study. The change of intestinal permeability was determined by urine lactulose/ mannitol ratio (L/M), and the serum diamine oxidase (DAO) was measured. (2) 60 chronic severe hepatitis B patients were randomly divided into two groups: the control group and the treated group, each group has 30 cases. Patients in the control group received standard treatment for 2 weeks, however, in addition to standard treatment, patients in the treated group also received glutamine 10g tid. Endotoxin (ET), DAO and L/M were compared between the two group.
RESULTS(1) Compared to healthy controls, the level of L/M and DAO was significantly increased in chronic severe hepatitis B patients (t = 2.762, P less than 0.01 or t = 6.326, P less than 0.01). (2) Compared to the control group, ET, DAO and L/M were significantly lower 2 weeks after treatment (F = 11.662, P less than 0.01; F = 12.699, P less than 0.01; F = 19.981, P less than 0.01).
CONCLUSION(1) There is an early intestinal mucosa barrier damage in chronic severe hepatitis B patients. (2) Compared to standard treatment, adding glutamine can reverse intestinal mucosa barrier damage.
