The experimental results of GVHD following orthotropic liver transplantation.
- Author:
Gui-ling YAO
1
;
Wei LI
;
Ai-bing LIU
;
Hui LIANG
;
Li-jie SONG
;
Mei-e WANG
;
Yuan-ming LIU
;
Li WANG
;
Hai-yan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adult; Aged; Bacterial Infections; etiology; Bone Marrow Diseases; blood; etiology; Bone Marrow Examination; Cause of Death; Chimerism; Cytokines; blood; Female; Graft vs Host Disease; blood; diagnosis; etiology; mortality; Humans; Interleukins; blood; metabolism; Leukopenia; blood; etiology; Liver Transplantation; adverse effects; Male; Middle Aged; Retrospective Studies; Transplantation, Autologous; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Hepatology 2009;17(11):856-860
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze experimental results of Graft-versus-host disease (GVHD) after liver transplantation.
METHODS13 cases of GVHD out of the 1013 liver transplantation between 2002-2008 were analysed. Routine blood test, liver function and microorganisms test were done in all of the 13 cases, bone marrow test was done in 5 cases, liver pathological test was done in 5 cases, cytokines were analyzed in 4 cases, chimerism test was done in 6 cases.
RESULTSLeukocytes were reduced to various degree in all 13 cases, and were extremely low in 8 cases. Hematopoiesis was repressed in 4 cases. Normal liver function was found in 9 cases. Bacterium were found in blood, bile, wound secrete juice, excrement, phlegm of 10 cases. The pathological characteristics was in accordance with GVHD in 5 cases. The levels of IL-1 alpha, IL-1 beta, IL-2, IL-4 were low or undetectable. IL-10 was decreased in 4 cases but increased in 1 case. MCP-1, VEGF, IL-6, EGF, IL-8 were increasing or remained at high level during GVHD. TNF alpha was slightly increased. IFN gamma was only slightly changed before GVHD.
CONCLUSIONChimerism is a reliable but not unique evidence of GVHD.
