Modification of seaweed polysaccharide-agarose and its application as skin dressing (III)--skin regeneration with agarose grafting hyaluronic acid sponge.
- Author:
Jianyan HUANG
1
;
Lingmin ZHANG
;
Bin CHU
;
Peng CHEN
;
Shunqing TANG
Author Information
1. Biomedical Engineering Institute, Jinan University, Guangzhou 510632, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bandages;
Female;
Fibroblast Growth Factor 2;
physiology;
Hyaluronic Acid;
therapeutic use;
Mice;
Mice, Inbred C57BL;
Polysaccharides;
isolation & purification;
therapeutic use;
Random Allocation;
Seaweed;
chemistry;
Sepharose;
isolation & purification;
therapeutic use;
Surgical Sponges;
Wound Healing;
drug effects;
Wounds and Injuries;
therapy
- From:
Journal of Biomedical Engineering
2011;28(1):95-98
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, a kind of skin dressing, agarose- grafting- hyaluronic acid (Ag-g-HA) sponge was applied to test the modified agarose based scaffold for skin regeneration. The bFGF loading agarose-grafting hyaluronan scaffold had homogenous porosities, and the loaded bFGF was bioactive in 2 weeks. The Ag-g-HA sponge was applied into skin of mice, and it was found that the dressing promoted skin regeneration and no infection and leakage in lesion site took place. H&E staining results showed that the repaired skin was similar to autologous skin. These demonstrate that Ag-g-HA sponge has a promise in skin regeneration.
