Progress of nanometer vector polyethylenimine applied in gene therapy.
- Author:
Xiaoai CHEN
1
;
Yubin DENG
Author Information
1. Department of Pathophysiology, Zhongshan School of Medicine, SUN Yat-sen University, Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Genetic Therapy;
Genetic Vectors;
Humans;
Nanostructures;
chemistry;
Polyethyleneimine;
chemistry;
Stem Cell Transplantation;
methods;
Transfection;
methods
- From:
Journal of Biomedical Engineering
2011;28(1):195-198
- CountryChina
- Language:Chinese
-
Abstract:
Polyethylenimine (PEI) is a kind of nanometer nonviral vector frequently applied in gene transfection. It is simple and easy to prepare and to modify and relatively safe compared to viral vectors. In recent years, PEI has been utilized in many research areas for gene delivery to stem cells in vitro or targeted gene delivery to cells in the brain. This review reveals that the cytotoxicity and low transfection efficiency of PEI requires to be improved. However brain-targeted modification indicates the promising prospect of PEI for gene therapy in cerebrovascular diseases.
