Research progression of PPARgamma to bone remodeling.
- Author:
Yan WANG
1
;
Baoxin LI
;
Yukun LI
Author Information
1. Department of Endocrinology, The Third Hospital, Hebei Medical University, Shijiazhuang 050051, China.
- Publication Type:Journal Article
- MeSH:
Bone Remodeling;
physiology;
Humans;
Osteoblasts;
physiology;
Osteoclasts;
physiology;
PPAR gamma;
physiology
- From:
Journal of Biomedical Engineering
2011;28(1):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator activated receptor gamma interacts with bone morphogenetic protein, Wnt, TAZ, and insulin-like growth factor-I, which are required for the process of osteoblast differentiation, regulating the mesenchymal stem cells (MSCs) into adipocytes and osteoblasts differentiation, thus impact on the osteoblast-mediated bone formation in bone remodeling, and, through RANKL and other factors directly or indirectly, regulate osteoclast-mediated bone resorption. This article reviews new researches for the influence of peroxisome proliferator activated receptor gamma on osteoblast and osteoclast function in bone remodeling.
