PTD mediated protein transduction technology and its application in medical field.
- Author:
Nanhui YE
1
;
Yanyun LIN
;
Jianru PAN
;
Shutao LIU
;
Pingfan RAO
Author Information
1. Institute of Biotechnology, Fuzhou Univrsity, Fuzhou 350002, China.
- Publication Type:Journal Article
- MeSH:
Cell Membrane Permeability;
physiology;
Drug Delivery Systems;
methods;
Genetic Therapy;
Humans;
Protein Sorting Signals;
Protein Transport;
physiology
- From:
Journal of Biomedical Engineering
2011;28(2):401-404
- CountryChina
- Language:Chinese
-
Abstract:
The delivery of bioactive macromolecular substances into cells provides an efficient approach to changing cellular conditions, and is thus of enormously potential therapeutic significance. It has also been an extremely difficult approach due the the impediment and protective nature of cell membrance until the protein transduction domain's (PTD's) capability to ferry macromolecule across cell membrance was discovered. PTD's efficient transductive function has rendered an exciting promise to the clinical treatment of diseases, therapeutic proteins drug development, and basic medical and applied research. The technology has been successfully applied to deliver a variety of substances into cells or tissue organs, and its superior application values have been explicitly demonstrated.
