Developments in research of local bisphosphonate delivery system of implant denture.
- Author:
Chengcheng ZANG
1
;
Junjiang ZHAI
;
Yanhua MENG
;
Xing LIANG
Author Information
1. West China College of Stomatology, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Administration, Topical;
Bone Density Conservation Agents;
administration & dosage;
Bone Remodeling;
drug effects;
physiology;
Dental Implantation, Endosseous;
methods;
Dental Implants;
Diphosphonates;
administration & dosage;
Humans
- From:
Journal of Biomedical Engineering
2011;28(2):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Dental implant is an advanced prosthodontic treatment widely accepted by patients with missing tooth. However, peri-implant bone loss is still an important reason which limits wider application of the implants to a certain extent. Bisphosphonates is an osteoclastic bone resorption inhibitor that is widely used in clinical practice with the function of inhibiting bone resorption and increasing bone density. As the defect of systemic BPs treatment, local application of BPs in implant has become a research hotspot recently. Calcium phosphate ceramics, polylactic acid, fibrinogen film and collagen membrane have been reported as BPs carriers. This article summarizes the researches on the mechanism of bone regulation and local delivering system of BPs.
