Relationship between glypican-3 and Notch1 expressions in hepatocellular carcinoma.
- Author:
Fanli PENG
1
;
Ziqing WU
;
Xuenong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Hepatocellular; metabolism; pathology; Female; Glypicans; metabolism; Humans; Liver Neoplasms; metabolism; pathology; Male; Middle Aged; Receptor, Notch1; metabolism
- From: Journal of Southern Medical University 2013;33(4):590-597
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between the expressions of glypican-3 (GPC3) and Notch1 and their roles in the tumorigenesis and progression of hepatocellular carcinoma (HCC).
METHODSImmunohistochemistry and computerized image analysis were utilized to quantitatively detect the expressions of GPC3 and Notch1 in 30 HCC tissue specimens.
RESULTSIn the 30 HCC specimens, GPC3 expression decreased significantly as the grade of tumor differentiation increased (P<0.05 or P<0.01), while Notch1 expression presented with a reverse pattern of changes (P<0.05 or P<0.01). An obvious negative correlation was found between the expressions of GPC3 and Notch1 in HCC tissues (rp=-0.607, P=0.000; r=-0.692, P=0.000).
CONCLUSIONThe expressions of GPC3 and Notch1 show a negative correlation in HCC, suggesting a possible mechanism for mutual regulation between them to contribute to the tumorigenesis and progression of HCC.
