Pulmonary expression levels of fibroblast growth factor receptors and lung fibrosis in mice at different ages.
- Author:
Xiaoxi LI
1
;
Hongen CHANG
;
Wenqing NAI
;
Xiaoyan BAI
;
Ying SUN
;
Yanlin YU
;
Meng DAI
Author Information
- Publication Type:Journal Article
- MeSH: Aging; physiology; Animals; Lung; metabolism; pathology; Male; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis; metabolism; pathology; physiopathology; Receptors, Fibroblast Growth Factor; classification; metabolism; Signal Transduction
- From: Journal of Southern Medical University 2013;33(4):607-610
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation of pulmonary expressions of fibroblast growth factor receptors (FGFR1-4) with lung fibrosis and aging.
METHODSReal-time fluorescence quantitative PCR was used to detect the expression levels of FGFR1-4 in the lung tissues, and lung fibrosis was observed by HE and Masson staining in mice at different ages.
RESULTSThe 4 subtypes of FGFR showed different expression levels in the lung tissues of mice, and FGFR2 had the highest expressions. The expression levels of all the 4 FGFR subtypes in 8-month-old mice were significantly lower than those in 5-week-old mice. The 8-month-old mice tended to present with histological changes of lung fibrosis.
CONCLUSIONFGFR expressions is down-regulated with aging in mice. Among the FGFR subtypes, FGFR2 is expressed at the highest level. The occurrence of lung fibrosis with aging is probably associated with down-regulated FGFR expression. FGF/FGFR signaling may participate in the aging process and regulation of lung fibrosis.
