Association between APOBEC3G polymorphisms and susceptibility to chronic hepatitis B.
- Author:
Zhiyi YOU
1
;
Fuyuan ZHOU
;
Xionghu WANG
;
Chuming CHEN
;
Junhua ZHOU
;
Dejian ZHAO
;
Guifang HU
Author Information
- Publication Type:Journal Article
- MeSH: APOBEC-3G Deaminase; Adult; Alleles; Case-Control Studies; Cytidine Deaminase; genetics; Female; Genetic Predisposition to Disease; Genotype; Hepatitis B, Chronic; genetics; Humans; Male; Polymorphism, Single Nucleotide; Young Adult
- From: Journal of Southern Medical University 2013;33(5):769-771
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between rs185983011 single-nucleotide polymorphisms (SNP) of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and the susceptibility to chronic hepatitis B.
METHODSThe blood samples were collected from 186 healthy subjects and 159 patients with chronic hepatitis B. The rs185983011 SNP was detected and genotyped by sequencing with Sanger's method to analyze the relationship between rs185983011 SNP and chronic hepatitis B.
RESULTSOnly C/C and C/T genotypes of the alleles of rs185983011 SNP were found in the tested subjects, and the C/C genotype was predominant (97.7%). The distribution frequencies of rs185983011 SNP genotypes and alleles showed no significant difference between healthy subjects and patients with chronic hepatitis B (P>0.05).
CONCLUSIONThe predominant genotype of rs185983011 SNP of APOBEC3G is C/C in the tested subjects, and rs185983011 SNP does not appear to associate with the susceptibility to chronic hepatitis B.
