OBJECTIVETo explore the core mechanism of cell cycle compensation using a mathematical model.

METHODSA set of ordinary differential equations were used to describe the interactions between the core cell cycle molecules. Continuous and cyclic changes of the concentrations of these molecules were computed to capture the discrete events of molecular interactions.

RESULTSThe calculated molecule concentrations and captured signaling events agreed with the experimental results.

CONCLUSIONE2F transcription factor 1 is the pivotal element linking the positive and negative feedbacks and regulating G1/S and G2/M phase compensation.