Expression and clinical significance of secretory leucocyte protease inhibitor in colon carcinoma.
- Author:
Jiubing GUO
1
;
Guoxin LI
;
Jianmin ZHUANG
;
Chenghong JI
;
Feng LIU
;
Guoquan TAO
;
Hanzhang DONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Colonic Neoplasms; metabolism; pathology; Electrophoresis, Microchip; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Secretory Leukocyte Peptidase Inhibitor; metabolism
- From: Journal of Southern Medical University 2013;33(6):898-901
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of secretory leucocyte protease inhibitor (SLPI) in colon cancer and their clinical significance.
METHODSImmunohistochemistry was performed to detect the SLPI expression in colon cancer tissue microarray. The expression of SLPI was scored by two pathologists and was analyzed using Χ(2) test to explore its influence on the pathologic characteristics of colon carcinoma.
RESULTSSLPI was up-regulated in colon cancer tissue compared to normal mucosa. Overexpression of SLPI protein was correlated with differentiation grade (low differentiation: 42.1% vs 57.9%; moderate/well differentiation: 2.3% vs 97.7%, TNM stages(III-IV:29.4% vs 70.6%;I-II:3.1% vs 96.9%), lymph node metastasis (28.6% vs 71.4%) and distant metastasis (84.6% vs 15.4%), but not with patient age or sex.
CONCLUSIONSLPI overexpression correlates with aggressive pathologic characteristics of colon cancer and it may server as prognostic factor of colon cancer patients. Further research will be carried out to verify whether SLPI can become a new target for colon cancer treatment.
