Expression of Nusap1 in the surgical margins of hepatocellular carcinoma and its association with early recurrence.
- Author:
Meng ZHANG
1
;
Dinghua YANG
;
Xiao LIU
;
Yan LIU
;
Jiankui LIANG
;
Hua HE
;
Kebo ZHONG
;
Liang LIN
;
Guogui TAO
;
Chi ZHANG
;
Jie ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Carcinoma, Hepatocellular; metabolism; pathology; surgery; Female; Humans; Immunohistochemistry; Liver Neoplasms; metabolism; pathology; surgery; Male; Microtubule-Associated Proteins; metabolism; Middle Aged; Neoplasm Recurrence, Local; pathology; Young Adult
- From: Journal of Southern Medical University 2013;33(6):937-inside back cover
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of Nusap1 of surgical margins in hepatocellular carcinoma (HCC) and investigate its association with early tumor recurrence.
METHODSThe expression of Nusap1 in the surgical margins of HCC, which were histopathologically negative for tumor cells, was examined using immunohistochemistry in 61 HCC cases.
RESULTSFifteen of 21 (71.4%) cases with immunohistochemical positivity for Nusap1 expression in the surgical margins had early recurrence of HCC, a rate significantly higher than that in patients with negative Nusap1 expression (12/40, 30%) (P<0.05).
CONCLUSIONSNusap1 expression in the surgical margins of HCC is closely correlated to early postoperative recurrence and can serve as an indicator for predicting early recurrence of HCC.
