Effects of local application of zoledronic acid on bone healing of tooth extraction in rats
10.3760/cma.j.issn.1002-0098.2011.07.005
- VernacularTitle:局部应用唑来膦酸对拔牙创骨愈合影响的动物实验
- Author:
Ting MA
1
;
Wen-Yi ZHANG
;
Jian ZHANG
;
Ming WANG
;
Cai-Wen CUI
Author Information
1. 天津医科大学口腔医院
- Keywords:
Vascular endothelial growth factor;
TypeⅠcollagen;
Zoledronic acid
- From:
Chinese Journal of Stomatology
2011;46(7):403-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of local application of zoledronic acid(ZA)on the expression of typeⅠcollagen and vascular endothelial growth factor(VEGF). Methods Fifty-four male Wistar rats were divided into ZA group, gelatin sponge group, and blank control group after one-side tooth extraction. The expression of typeⅠcollagen and VEGF were detected with SP immunohistochemistry method 1, 2 and 4 weeks after operation. Results The gray value of typeⅠcollagen in ZA group (60.00±1.81,63.47±3.02)was lower than those in gelatin sponge group(68.58±2.90,71.15±5.57) and blank control group(69.16±9.63,72.50±4.10,P<0.05)in the 1 and 2 week.In the ZA and gelatin sponge groups, the gray values of typeⅠcollagen were higher in the 4th week than in the 1st and 2nd week(P<0.05). The expression of VEGF was higher in ZA group (69.93±2.74)than in gelatin sponge group(60.86±4.79)and blank control group (61.52±2.28)in the 1st week(P<0.05). There was significant difference in VEGF expression between the 2nd week and 1st and 4th week(P<0.05). Conclusions Local application of ZA could enhance the expression of typeⅠcollagen but inhibit the expression of VEGF in the early stage.
