A retrospective study of oral squamous cell carcinomas originated from oral submucous fibrosis

VernacularTitle:口腔黏膜下纤维性变癌变的病理及临床生物学行为回顾性研究
Author: Feng GUO ¹ ; Xin-Chun JIAN ; Shang-Hui ZHOU ; Ning LI ; Yan-Jia HU ; Zhan-Gui TANG
Author Information

1. 中南大学湘雅医院
Keywords: Carcinoma,squamous cell; Oral submucous fibrosis; Mouth neoplasms
From: Chinese Journal of Stomatology 2011;46(8):494-497
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical characteristics,pathological and biological behaviors of oral squamous cell carcinomas(OSCC) originated from oral submucous fibrosis(OSF). Methods A total of 528 patients with OSCC treated at Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University from 2002 to 2010 were divided into two groups, OSCC originated from OSF and OSCC not originated from OSF. The clinical data regarding age, gender, location, pathological type, metastasis and recurrence rate of these patients were analyzed retrospectively. ResultsThe mean age of the group of OSCC originated from OSF (45.8 years) was younger than that of the group of OSCC not originated from OSF(55.9 years). The and recurrence rate of the group of OSCC originated from OSF(13.5%, 39.1%)was higher than that of the group of OSCC not originated from OSF(7.6%, 27.8%.). Conclusions OSCC originated from OSF occurs at younger age and more in male, and is clinically more invasive and metastatic.