Effect of parasympathectomy on the salivary secretion of submandibular gland in rats.
- Author:
Wei QI
1
;
Ning-Yan YANG
;
Xiao-Feng SHAN
;
Feng-Ying FU
;
Li-Ling WU
;
Guang-Yan YU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Male; Parasympathectomy; methods; Random Allocation; Rats; Rats, Sprague-Dawley; Saliva; secretion; Salivation; Submandibular Gland; secretion; Xerostomia; therapy
- From:Chinese Journal of Stomatology 2011;46(9):519-523
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of parasympathectomy on secretion of submandibular glands and the feasibility of treatment for xerostomia in rats.
METHODSTwenty Sprague-Dawley male rats weighing 200 - 300 g were randomly divided into the experimental group (n = 12), in which the right chorda-lingual nerve was cut, and the control group (n = 8). The secretion of submandibular gland was measured for 5 min by Schirmer test for both groups.
RESULTSThe stimulated saliva flow rate decreased on 1st, 12th and 24th week after denervation in the right operated submandibular glands (P < 0.05). No difference in secretion was found between the left non-operated glands and the control group. Comparing with the left non-operated gland and the control gland, the saliva flow rate at rest in the right operated submandibular gland increased on the 1st, 12th and 24th week (P < 0.05).
CONCLUSIONSAfter parasympathectomy of rat submandibular glands, the saliva flow rate at rest increased in the denervated gland, which suggests that parasympathectomy of submandibular gland might be used as a therapy for xerostomia.
