Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice.
- Author:
Yunru LIU
1
;
Qiongjun XU
1
;
Yaping MA
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Formaldehyde; toxicity; Gastric Lavage; Lipid Peroxidation; Liver; drug effects; metabolism; pathology; Male; Malondialdehyde; metabolism; Mice; Mice, Inbred ICR; Superoxide Dismutase; metabolism
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2014;32(5):376-377
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.
METHODSThirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.
RESULTSThe activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).
CONCLUSIONA certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.
