Increased CD5 + B Cells in Neonatal Infections.
- Author:
Woo Gill LEE
- Publication Type:Original Article
- Keywords:
CD5+ B cell;
Neonatal infections
- MeSH:
Autoimmune Diseases;
B-Lymphocytes*;
Humans;
Infant, Newborn
- From:Korean Journal of Immunology
1997;19(3):399-406
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: CD5+ B (B1) cell is a subpopulation of B cells and CD5+ B cells constitute a large fraction of B cells in neonates. CD5 B cells are closely related with autoimmune diseases but the roles and functions in neonates are still unknown. The quantitative changes of CD5+ B cells in neonatal infections were examined to investigate the involvement of CDS+ B cells in neonatal immune reaction to general immunologic stimuli such as infections. Methods: Ten normal neonates and eight neonates with acute febrile diseases were studied. Venous blood was drawn and mononuclear cells were separated by Ficoll-Hypaque. Half was double-stained with FITC-conjugated anti-CD5 and PE-conjugated anti-CD19, and another half with FITC-conjugated anti-CD4 and PE-conjugated anti-CD8. Stained samples were analyzed using fluorescent-activated cell sortor. ...continue...
