The relationship between the C589T polymorphism of IL-4 gene and cholelithiasis.
- Author:
Xiao-ming ZHUANG
1
;
Hong XIAO
;
Yuan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; Cholecystolithiasis; ethnology; genetics; Choledocholithiasis; ethnology; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-4; genetics; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic; genetics
- From: Chinese Journal of Surgery 2005;43(13):850-852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between IL-4 gene polymorphism and cholelithiasis in Chinese population.
METHODSPolymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of IL-4 gene in 81 cholecystolithiasis, 41 patients with biliary duct stone.
RESULTSThere were no significant differences of the IL-4 gene polymorphism genotypes and alleles between 81 cholecystolithiasis patients (CC11.1%, CT34.6%, TT54.3%; C28.4.7%, T71.6%). There were significant differences of the IL-4 gene polymorphism genotypes and alleles between 41 patients with biliary duct stone (CC48.8%, CT36.6%, TT14.6%; C67.1%, T32.9%).
CONCLUSIONSThe C589T polymorphism of IL-4 gene was not associated with cholecystolithiasis patients in Chinese, but was related to patients with biliary duct stone in Chinese.
