Establishment of maca mulatta model of resuscitation after selective cerebral ultra-deep hypothermic blood flow occlusion.
- Author:
Jie ZHOU
1
;
Zhong-tang FENG
;
Yong-jun GAO
;
Shao-long FANG
;
Deng-li FU
;
Ji-yao JIANG
;
Wei XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; etiology; prevention & control; Carotid Artery, Common; surgery; Disease Models, Animal; Extracorporeal Circulation; adverse effects; methods; Hypothermia, Induced; Macaca mulatta; Male; Reperfusion; methods; Resuscitation; Vertebral Artery; surgery
- From: Chinese Journal of Surgery 2005;43(13):889-891
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the feasibility of resuscitation after selective cerebral ultra-deep hypothermia and blood flow occlusion.
METHODSTen 4-10 year-old maca mulattas were divided into 3 groups: four-vessel occlusion group, two-vessel occlusion group and identical temperature perfusion group. MRI were examinated before and after operation, the vital signs and the hemodynamical parameters were observed during the experiment, neurological deficient evaluation was performed after operation.
RESULTSIn all of the ten monkeys, the hemodynamical parameters of two-vessel occulation were steady during the operation, and all of them lived after filling 60 minutes. MRI were normal after operation, and the function of neurological deficient scale was normal. The others of identical temperature perfusion group and four-vessel occlusion group were not resuscitation after filling 60 minutes and died.
CONCLUSIONMonkey could resuscitate from selective cerebral ultra-deep hypothermia and blood flow occlusion of bilateral common carotid artery in 60 minutes.
