Characterization of focal liver lesions using an innovative contrast-enhanced ultrasound technique.
- Author:
Hui-xiong XU
1
;
Guang-jian LIU
;
Ming-de LÜ
;
Xiao-yan XIE
;
Zuo-feng XU
;
Yan-ling ZHENG
;
Jin-yu LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Female; Humans; Liver Diseases; diagnostic imaging; Male; Middle Aged; Sulfur Hexafluoride; Ultrasonography; methods
- From: Chinese Journal of Surgery 2005;43(21):1375-1378
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the clinical performance of an innovative contrast-enhanced ultrasound (CEUS) technique in characterization of focal liver lesions (FLL).
METHODSCEUS was performed in 505 patients with FLLs. A sulfur hexafluoride-filled microbubble ultrasound contrast agent and a continuous real-time imaging technique of contrast pulse sequencing were used. The observation items included initial nodule enhancement time, enhancement level and pattern, and dynamic evolution of enhancement along with the CEUS phases.
RESULTSThere were similar findings for both malignant and benign FLLs in initial enhancement time and enhancement level on CEUS. The dynamic evolution of enhancement along with enhancement phase was the most significant parameter for characterization of FLLs. Most malignant lesions showed enhancement at arterial phase and hypo-enhancing at late phase, whereas the benign lesions presented enhancement at arterial phase and persistent hyper- or iso-enhancing until late phase. Using these characteristics as a diagnostic criteria, the sensitivity, specificity, positive predicative value, negative predicative value and accuracy of CEUS in identifying malignant FLLs were 95.7% (313/327), 86.0% (153/178), 92.6% (313/338), 91.6% (153/167) and 92.3% (466/505), respectively.
CONCLUSIONSCharacterization of FLLs by using the innovative CEUS technique is recommendable due to its safety, facility and high accuracy.