D8/17 Expression on B Lymphocytes of Children and Adolescents with Tic Disorder.
- Author:
Young Gun OH
1
;
Tae Won PARK
;
Yong Woo JUNG
;
Sang Keun CHUNG
;
Young Chul CHUNG
;
Jong Chul YANG
Author Information
1. Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences, Jeonju, Korea. ptaewon@jbnu.ac.kr
- Publication Type:Original Article
- Keywords:
Tic Disorder;
D8/17;
ASO;
PANDAS;
FACS
- MeSH:
Adolescent*;
Anorexia Nervosa;
B-Lymphocytes*;
Child*;
Humans;
Obsessive-Compulsive Disorder;
Rheumatic Fever;
Tic Disorders*;
Tics*;
Tourette Syndrome
- From:Journal of the Korean Academy of Child and Adolescent Psychiatry
2013;24(3):151-156
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: It has been reported that higher percentage of B cells react with monoclonal D8/17 antibody in patients with rheumatic fever, childhood onset obsessive-compulsive disorder, Tourette's disorder, or prepubertal anorexia nervosa. The purpose of this study is to replicate the previous studies in a Korean young population with tic disorder and to identify any relationship between D8/17 and clinical symptoms. METHODS: The binding of D8/17 to B cells was determined in patients with tic disorder (N=21) and healthy controls (N=9) by Fluorescence-Activated Cell Sorter analysis. RESULTS: In the sample examined by this study, the average percentage of B cells expressing D8/17 in tic disorder was 2.05%; healthy controls was 3.15%. No statistically significant differences were found in the mean percentages of D8/17 between the two groups. CONCLUSION: The expression of D8/17 in B cells was very low in this study. No subjects with tic disorder or healthy controls was above 12% in D8/17 positive proportion. Further studies, including higher number of patients and control group members, should be performed.
