Loss of heterozygosity on chromosome 3p in thyroid tumors.
- Author:
Meng-Jun HU
1
;
Hang-Di XU
;
Ren ZHOU
;
Xiu-Fang LI
;
Hai-Yong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma, Follicular; genetics; Adenoma; genetics; Adult; Aged; Carcinoma, Papillary; genetics; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 3; genetics; Female; Genes, Tumor Suppressor; physiology; Heterozygote; Humans; Loss of Heterozygosity; Male; Microsatellite Repeats; Middle Aged; Thyroid Neoplasms; genetics; Young Adult
- From: Chinese Journal of Pathology 2008;37(5):305-308
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the loss of heterozygosity (LOH) on chromosome 3p in thyroid tumors.
METHODSLOH at 11 microsatellite loci was analyzed in 74 cases of thyroid tumors (including 20 follicular adenomas, 24 follicular thyroid carcinomas and 30 papillary thyroid carcinomas) by polymerase chain reaction and silver stain.
RESULTSLOH on chromosome 3p was detected in 71% of follicular thyroid carcinoma (17/24), 30% of the papillary thyroid carcinoma (9/30) and 10% of the follicular adenoma (2/20) case. Two minimal common deleted regions (CDR) (3p26-pter and 3p14.2-3p22) involving significant sites of LOH has identified in follicular thyroid carcinoma. There was also one CDR (3p25. 2-26.1) in papillary thyroid carcinoma.
CONCLUSIONSLOH is more frequently identified in follicular thyroid carcinoma than in papillary thyroid carcinoma and follicular adenoma. The 3 CDR on chromosome 3p may harbor tumor suppressor genes involved in the pathogenesis of follicular thyroid carcinoma and papillary thyroid carcinoma.
