Primary diffuse large B-cell lymphoma of central nervous system belongs to activated B-cell-like subgroup: a study of 47 cases.
- Author:
Jing CHENG
1
;
Pin TU
;
Qun-li SHI
;
Hang-bo ZHOU
;
Zhi-yi ZHOU
;
You-cai ZHAO
;
Heng-hui MA
;
Xiao-jun ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; B-Lymphocytes; pathology; Biomarkers, Tumor; analysis; Central Nervous System; Central Nervous System Neoplasms; diagnosis; Female; Humans; Lymphoma, B-Cell; diagnosis; metabolism; Lymphoma, Large B-Cell, Diffuse; diagnosis; metabolism; Male; Middle Aged; Prognosis; Young Adult
- From: Chinese Journal of Pathology 2008;37(6):384-389
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the histogenetic origin of primary central nervous system diffuse large B-cell lymphoma (DLBCL) with respect to the stage of B-cell differentiation, and identification of the relevant prognostic markers.
METHODSImmunohistochemical staining (EnVision method) for CD10, bcl-6, MUM-1, CD138 and FOXP1 antigens was performed on 47 paraffin-embedded sections.
RESULTSCD10, bcl-6, MUM-1 and FOXP1 expression in the tumor cells were 6.4%, 53.2%, 91.5% and 93.6% respectively. There was no expression of CD138 in all the cases. Among the 47 patients, 43 cases (91.5%) showed an activated B-cell-like (ABC) phenotype: 21 (44.7%) were bcl-6+ and MUM-1+, suggesting an "activated germinal center (GC) B-cell-like" in origin; 22 (46.8%) were exclusively MUM-1+, suggesting an "activated non-GCB" in origin. No significant correlation of the classification and FOXP1 expression found on the outcome (P=0.279 and P=0.154).
CONCLUSIONSMost primary central nervous system DLBCL are shown belonging to the ABC subgroup, suggesting that primary central nervous system DLBCL is quite similar to a DLBCL subset, which is derived from late GC to early post-GC B cell. The classification and FOXP1 expression do not show prognostic value in primary central nervous system DLBCL.